Symbol
Name
ID

Prkdc
protein kinase, DNA activated, catalytic polypeptide
MGI:104779

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	B lymphocytopenia	T lymphocytopenia	Abnormal natural killer cell morphology
Disease(s) Associated with PRKDC
immunodeficiency 26

Mouse Phenotypes

hematopoietic system phenotype

decreased thymocyte apoptosis

decreased B cell proliferation

decreased T cell proliferation

abnormal thymus morphology

abnormal thymus lobule morphology

absent thymus cortex

abnormal thymus corticomedullary boundary morphology

absent thymus corticomedullary boundary

small thymus

thymus hypoplasia

decreased thymocyte number

thymus cyst

abnormal B cell differentiation

abnormal class switch recombination

abnormal immunoglobulin V(D)J recombination

abnormal immunoglobulin heavy chain V(D)J recombination

abnormal immunoglobulin light chain V-J recombination

arrested B cell differentiation

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal T cell receptor V(D)J recombination

abnormal T cell receptor alpha chain V-J recombination

abnormal T cell receptor beta chain V(D)J recombination

abnormal T cell receptor delta chain V(D)J recombination

decreased double-negative T cell number

increased double-negative T cell number

decreased double-positive T cell number

increased double-positive T cell number

arrested T cell differentiation

myeloid hyperplasia

decreased bone marrow cell number

increased bone marrow cell number

increased eosinophil cell number

decreased erythrocyte cell number

decreased mean corpuscular hemoglobin concentration

increased mean corpuscular volume

increased neutrophil cell number

decreased granulocyte number

increased granulocyte number

thrombocytopenia

increased plasmacytoid dendritic cell number

decreased mature B cell number

absent mature B cells

decreased B-1 B cell number

decreased B-1a cell number

increased B-1b cell number

increased plasma cell number

decreased B cell number

absent B cells

decreased pre-B cell number

absent pre-B cells

increased B cell number

decreased NK cell number

increased NK cell number

abnormal T cell number

increased central memory CD4-positive, alpha-beta T cell number

decreased effector memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased NK T cell number

decreased alpha-beta T cell number

increased alpha-beta T cell number

decreased gamma-delta T cell number

decreased T cell number

absent T cells

decreased single-positive T cell number

increased T cell number

decreased lymphocyte cell number

decreased macrophage cell number

increased macrophage cell number

increased monocyte cell number

decreased leukocyte cell number

decreased hematopoietic stem cell number

pancytopenia

abnormal lymphocyte morphology

abnormal spleen morphology

small spleen

spleen hypoplasia

abnormal spleen white pulp morphology

decreased spleen white pulp amount

decreased splenocyte number

abnormal B cell physiology

decreased IgG level

decreased IgM level

increased IgM level

decreased immunoglobulin level

abnormal NK cell physiology

impaired natural killer cell mediated cytotoxicity

abnormal hematopoietic stem cell physiology

Availability

Mouse Genotype

Prkdc^berty/Prkdc^berty

Prkdc^em2(IMPC)Ics/Prkdc^em2(IMPC)Ics

Prkdc^hanky/Prkdc^hanky

Prkdc^m1Anu/Prkdc^m1Anu

Prkdc^m1Btlr/Prkdc^m1Btlr

Prkdc^m2Btlr/Prkdc^m2Btlr

Prkdc^m3Btlr/Prkdc^m3Btlr

Prkdc^m4Btlr/Prkdc^m4Btlr

Prkdc^m5Btlr/Prkdc^m5Btlr

Prkdc^m6Btlr/Prkdc^m6Btlr

Prkdc^m7Btlr/Prkdc^m7Btlr

Prkdc^M8Btlr/Prkdc^M8Btlr

Prkdc^M9Btlr/Prkdc^M9Btlr

Prkdc^M10Btlr/Prkdc^M10Btlr

Prkdc^M11Btlr/Prkdc^M11Btlr

Prkdc^m12Btlr/Prkdc^m12Btlr

Prkdc^m13Btlr/Prkdc^m13Btlr

Prkdc^m14Btlr/Prkdc^m14Btlr

Prkdc^M15Btlr/Prkdc^M15Btlr

Prkdc^M16Btlr/Prkdc^M16Btlr

Prkdc^m17Btlr/Prkdc^m17Btlr

Prkdc^m18Btlr/Prkdc^m18Btlr

Prkdc^m19Btlr/Prkdc^m19Btlr

Prkdc^scid/Prkdc^scid

Prkdc^tm1.1Bpcc/Prkdc^tm1.1Bpcc

Prkdc^tm1Fwa/Prkdc^tm1Fwa

Prkdc^tm1Gcl/Prkdc^tm1Gcl

Prkdc^tm1Get/Prkdc^tm1Get

Prkdc^M8Btlr/Prkdc⁺

Prkdc^M9Btlr/Prkdc⁺

Prkdc^M10Btlr/Prkdc⁺

Prkdc^M11Btlr/Prkdc⁺

Prkdc^{Tg(INS-PDE2)5-1Lmb}/?

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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